Due to various simple reasons most of the authors (new and less experienced) having novel data and results finding difficulty to publish in well-known peer reviewed international journals. Here, the best way to construct the manuscripts to attract the editors and the papers get published will be explained for better understanding. Further, the credibility of scientific is getting damaged many times due to ethical breaches in its research and publication practices. These unwanted practices come in place due to increased pressure to publish, conflicts of interest, and ethical committee restrictions on research and mostly these things happen due to a lack of knowledge rather than intentions. Here, I will be discussing the ethics in publishing as well.