Objective: Previously published data on the COVID-19 infection has shown that older age group adults are more vulnerable than the young age group. The present study aims to analyze the available data in Center for Disease Control (CDC) and World Health Organization (WHO) on mortality in the older adult population compared with its younger counterparts.
Design: In this study, we focused distribution of mortality rate among the different age groups due to COVID-19 infection among 8,786,264 subjects in USA during the year 2020-2021. This information was collected from the public resources available in Center for Disease Control (CDC) and World Health Organization (WHO). We used computational techniques with Python tools and curated the available data from the above two resources. We used multivariable logistic regression to examine the association of pre-existing health conditions with COVID-19 deaths.
Results: A total of 8,786,264 subjects were analyzed. The mortality rate in patients aged higher than 85 years was 2,518,191 (28.66%). In 75-85 years of age, the mortality rate was 2,470,115 (28.11%). In 65-74 years the rate was 2,041,177 (23.23%). 55-64 years was 1,132,914 (12.89%). 45-54 years was 427,750 (4.87%). 35-44 years was 137,943 (1.57%). 25-34 years was 47,537 (0.54%). Lastly, 1-24 years was 10,642 (0.12%). To summarize, the key findings of this analysis is an exponential increase of COVID-19-related mortality exists with age. Previous studies has shown that during aging, the immune system activation decline in its function called immunosenescence, which can hampers pathogen recognition, alert signaling and clearance. Further it is also shown that during aging, chronic increase in systemic inflammation arises from an overactive, and might be responsible for the excessive lung damage.
Conclusion: Based on our studies it is implied that the proper medical treatment with the use of antivirals in old age populations is primarily needed for the COVID-19 infections.
December 28, 2025