Applied – ASSET https://assetonline.org Thu, 25 Dec 2025 20:09:12 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 https://assetonline.org/wp-content/uploads/2021/03/cropped-icon-32x32.png Applied – ASSET https://assetonline.org 32 32 Hydroponics: The Future of Farming https://assetonline.org/hydroponics-the-future-of-farming/ Thu, 25 Dec 2025 20:09:12 +0000 https://assetonline.org/?p=5935

Hydroponic farming is a way to grow plants without using any soil. Instead, the plants get all their food from a special nutrition rich water as medium. This method is very important today because it helps us grow plants even during extreme weather conditions or water scarcity. Further, the use of harmful fertilizers is minimized. The aim is to see if we could grow plants faster in small spaces. We used a “Deep Water Culture” system, which uses a water tank and air pumps to keep the roots healthy. We found that plants in this system grow much quicker than those in regular soil. Hydroponics farming is a sustainable method, helping meet present and growing food needs.

Authors List :
Zareena Asim, Azkiya Fatima, Salma Azhar Khan, Laiba Fatima, Dr. Fakhra Tabassum
Presenting Author :
Zareena Asim, Azkiya Fatima
Affiliations :
A.M.U. Girl's School, and A.B.K. Girls School. Aligarh Muslim University, Aligarh, India
Email :
zareenaasim48@gmail.com
Key Words (5 Words Maximum) :
Hydroponic farming, sustainable farming, soil-less farming
]]> Studies on green synthesis of Moringa oleifera nanoparticles for determining its biological properties https://assetonline.org/studies-on-green-synthesis-of-moringa-oleifera-nanoparticles-for-determining-its-biological-properties/ Wed, 24 Dec 2025 21:36:15 +0000 https://assetonline.org/?p=5882 The present study explores the green synthesis of silver nanoparticles (AgNPs) using Moringa oleifera extracts as an eco-friendly and sustainable approach to nanotechnology. Moringa oleifera, medicinal plants are rich in phytochemicals such as flavonoids, phenolics, and alkaloids which act as reducing and stabilizing agents. Plant-mediated synthesis offers a cost-effective and non-toxic alternative to conventional chemical methods, utilizing bioactive compounds in Moringa oleifera to reduce and stabilize nanoparticles. The synthesized nanoparticles were characterized through new techniques. Furthermore, their biological properties were systematically evaluated, to assess its potential applications as antimicrobial agent in medicine. Results demonstrated that Moringa oleifera-derived nanoparticles exhibit significant biological efficacy, highlighting their promise as natural agents for therapeutic use. This work shows the importance of integrating green chemistry principles with nanotechnology to advance sustainable innovations in biological sciences. The biologically produced AgNPs is being evaluated for its antimicrobial activity against the environmental bacteria.

Authors List :
Sara Syed and M. Asimuddin M
Presenting Author :
Sara Syed
Affiliations :
G. M. Reddy Research Foundation, Hyderabad, TG, India
Email :
kj.bmmrc@gmail.com
Key Words (5 Words Maximum) :
Moringa oleifera, Moringa oleifera extracts, antimicrobial activity
]]> Role of artificial intelligence (AI) in pharmacogenomics of cancer drugs, focusing on breast cancer therapeutics https://assetonline.org/role-of-artificial-intelligence-ai-in-pharmacology-of-cancer-drugs-focusing-on-breast-cancer-therapeutics/ Wed, 24 Dec 2025 16:29:04 +0000 https://assetonline.org/?p=5868 Pharmacology of cancer drugs, also known as oncology pharmacology, is a branch of pharmacology that focuses on the study of drugs and medications used for the treatment of cancer. It involves understanding how these drugs work, their mechanisms of action, pharmacokinetics (absorption, distribution, metabolism, and excretion), pharmacodynamics, adverse effects, and potential drug–drug interactions. In breast cancer, pharmacological strategies are guided by molecular subtype, including hormone receptor (HR) status, HER2 expression, and genomic alterations, allowing for increasingly personalized treatment approaches. Breast cancer therapeutics encompass cytotoxic chemotherapy, endocrine therapy, targeted molecular agents, antibody–drug conjugates (ADCs), and immunotherapy each acting through distinct pharmacological mechanisms. While conventional chemotherapy remains essential in many settings, targeted and endocrine therapies have significantly improved clinical outcomes with reduced systemic toxicity. Advances in molecular biology and personalized medicine continue to refine pharmacological strategies, improving survival outcomes and quality of life for breast cancer patients. This article will present the enumerate the drug mechanism, absorption, distribution, metabolism distribution and side effects in breast cancer treatments.
Precision oncology is revolutionizing cancer care by leveraging artificial intelligence (AI) to provide tailored treatments based on the genetic and molecular characteristics of each patient’s cancer. Here’s how AI is transforming the field: AI models can forecast how a patient’s cancer will react to certain drugs by analyzing data from prior clinical studies, genetic profiles, and real-world evidence. This helps in forecasting ineffective treatments, and reducing side effects. Optimize drug selection, ensuring the patient receives the best possible therapy. By combining AI with cutting-edge technologies like CRISPR and radiomics, precision oncology is paving the way for more effective, patient-centric cancer care. These advances highlight the synergy between computational tools and clinical expertise in tackling the complexity of cancer.

Authors List :
Kaiser Jamil
Presenting Author :
Kaiser Jamil
Affiliations :
Bhagwan Mahavir Medical Research Centre, Hyderabad-500004, Telangana, India
Email :
info@assetonline.org
Key Words (5 Words Maximum) :
Oncology, pharmacokinetics, antibody-drug conjugates, CRISPR, artificial intelligence
]]> Cerium Doping-Driven Electronic Modulation in Gd₂O₃ for Visible-Light Photocatalysis https://assetonline.org/cerium-doping-driven-electronic-modulation-in-gd%e2%82%82o%e2%82%83-for-visible-light-photocatalysis/ Tue, 23 Dec 2025 19:15:58 +0000 https://assetonline.org/?p=5856 We report the synthesis and detailed investigation of Gd₂O₃, Gd₁.₉₂Ce₀.₀₈O₃, Gd₁.₈₈Ce₀.₁₂O₃, and Gd₁.₈₄Ce₀.₁₆O₃ nanomaterials and their structure–property–activity relationships. X-ray diffraction confirmed the preservation of the cubic Gd₂O₃ phase for all compositions, with systematic peak shifts and broadening indicating successful substitutional incorporation of Ce and lattice distortion. FTIR and XPS analyses revealed a stable metal–oxygen framework with mixed Ce³⁺/Ce⁴⁺ redox states and an increased concentration of oxygen vacancies. BET surface analysis revealed an enhanced surface area and mesoporosity with increasing Ce content, while UV–Vis spectroscopy and Tauc plots demonstrated a progressive narrowing of the band gap and improved visible-light absorption. The photocatalytic activity was evaluated through dye degradation under visible-light irradiation, where Ce-doped samples exhibited significantly enhanced performance compared to pristine Gd₂O₃. Among them, Gd₁.₈₄Ce₀.₁₆O₃ achieved the highest degradation efficiency, attributed to efficient charge separation, defect-assisted electron transfer, and improved surface adsorption. Magnetic studies further indicated tunable magnetic behavior with Ce doping. These results demonstrate that Ce doping is an effective strategy to enhance the photocatalytic activity of Gd₂O₃, making it a promising material for visible-light-driven environmental remediation applications.

Authors List :
Alfaiz, Atif Hasan
Presenting Author :
Alfaiz, Atif Hasan
Affiliations :
Saiyyid Hamid Sr. Sec. School, Support Group for Education (SSGE), Aligarh Muslim University, Aligarh, UP-202002, India
Email :
mak402191@gmail.com
Key Words (5 Words Maximum) :
Nanoparticles, Nanosynthesis, Pollution degradation, Gadolinium oxide, Cerium Doping
]]> Beneficial Microbial Blueprint For Sustainable Future https://assetonline.org/beneficial-microbial-blueprint-for-sustainable-future/ Sun, 21 Dec 2025 10:19:19 +0000 https://assetonline.org/?p=5835

The growing challenges of climate change, environmental deterioration, and resource scarcity need a shift towards biological solutions. Microorganisms play a key role in preserving ecological balance and fostering sustainable growth through their various metabolic capacities. The concept of a beneficial microbial blueprint emphasizes the strategic identification, optimization, and deployment of functional microorganisms and their bioactive metabolites to address global concerns in agriculture, healthcare, industry, and the environment. Beneficial bacteria help to promote sustainable agriculture by cycling nutrients, fixing nitrogen, solubilizing phosphate, and controlling plant diseases, lowering the need for chemical fertilizers and pesticides. In healthcare and biotechnology, microbial secondary metabolites such as biosurfactants, bioactive pigments, enzymes and antibiotics provide sustainable alternatives with antibacterial, anticancer, and immunomodulatory therapeutic properties. Algae-derived substances, such as phycocyanin and polysaccharides from microalgae like Chlorella and Spirulina, have antiviral, neuroprotective and anti-inflammatory properties that can be used in the formulation of novel drugs. Furthermore, microbes are essential for ecological sustainability as they enable waste decomposition, bioremediation, and bioenergy production. Oleaginous algae such as Chlorella vulgaris efficiently convert biomass into precursors of bioethanol and biodiesel through fermentation pathways and lipid accumulation. Microbial fuel cells (MFCs) combine bioremediation with the generation of renewable energy by using electroactive bacteria that generate electricity directly from organic waste. Development in synthetic biology, omics technology including tools of artificial technology (AI) have significantly improved our capacity to harness microbial potential with increased specificity and efficiency. This talk will emphasize the use of beneficial bacteria as a sustainable blueprint for future innovations, boosting green technology and enhancing economic viability. Ultimately, orchestrating microorganisms to microbiomes will give a practical, effective, and sustainable strategy to accomplish the Sustainable Development Goals (SDGs) promoting resilience and guiding human development towards a harmonious coexistence on the planet earth.

Authors List :
Professor Hameeda Bee
Presenting Author :
Hameeda Bee
Affiliations :
Department of Microbiology, UCS, Osmania University
Email :
drhami2009@gmail.com
Key Words (5 Words Maximum) :
Microbes, Blue print, Health care, Agriculture, Environment, Sustainable
]]> Patient-Centric Pharmacovigilance: Development of a Mobile Application for Direct Adverse Drug Reaction Reporting. https://assetonline.org/patient-centric-pharmacovigilance-development-of-a-mobile-application-for-direct-adverse-drug-reaction-reporting/ Sat, 20 Dec 2025 19:00:59 +0000 https://assetonline.org/?p=5831

The increasing prevalence of adverse drug reactions (ADRs) poses a significant threat to public health, while underreporting remains a major limitation of existing pharmacovigilance systems. This paper presents the development of a mobile application, designed to facilitate direct, timely, and structured reporting of ADRs by patients and healthcare professionals.
The application features a user-friendly interface, standardizes ADR reporting forms, and secures data storage to ensure data integrity and confidentiality.
The application aims to improve accessibility, reduces reporting barriers, and enhances patient participation in pharmacovigilance. By empowering patients to report ADRs, we seek to improve drug safety and healthcare outcomes.
The ADR Reporter app demonstrates potential in bridging gaps in existing pharmacovigilance systems, promoting a scalable and patient-centric approach to medication safety, with future potential for integration into national ADR monitoring frameworks.

Authors List :
Mohammad Roohan, Aqsa Athar, Syed Ziaur Rahman
Presenting Author :
Mohammad Roohan, Aqsa Athar
Affiliations :
Department of Pharmacology, JNMC, AMU, Aligarh, India
Email :
m.roohan2010@gmail.com
Key Words (5 Words Maximum) :
ADR, Pharmacovigilance, Reporting
]]> Olfaction and Alzheimer’s Disease https://assetonline.org/olfaction-and-alzheimers-disease/ Mon, 30 Dec 2024 00:24:58 +0000 https://assetonline.org/?p=5761 Olfactory dysfunction, such as difficulty in detecting, identifying, or remembering odors, often precedes cognitive symptoms of AD by several years. This makes it a valuable early indicator for the disease. Patterns of olfactory impairment are linked to the atrophy of specific brain regions which can be detected using imaging and artificial intelligence much earlier than identified by the radiologist. ‎

Authors List :
Arham Aziz
Presenting Author :
Arham Aziz
Affiliations :
Sir Wilfrid Laurier Secondary School, London, ON, Canada
Email :
arham-aziz@outlook.com
Key Words (5 Words Maximum) :
Olfactory bulb, Alzheimer's disease, cognition, brain atrophy. artificial intelligence
]]> AI-driven Fast and Accurate Cell Phenotyping in Multiplex Images https://assetonline.org/ai-driven-fast-and-accurate-cell-phenotyping-in-multiplex-images/ Wed, 18 Dec 2024 01:50:55 +0000 https://assetonline.org/?p=5710 Highly multiplexed protein imaging is emerging as a potent technique for analyzing protein distribution within cells and tissues in their native context. However, existing cell annotation methods utilizing high-plex spatial proteomics data are resource intensive and necessitate iterative expert input, thereby constraining their scalability and practicality for extensive datasets. We introduce MAPS (Machine learning for Analysis of Proteomics in Spatial biology), a machine learning approach facilitating rapid and precise cell type identification with human-level accuracy from spatial proteomics data. Validated on multiple in-house and publicly available MIBI and CODEX datasets, MAPS outperforms current annotation techniques in terms of speed and accuracy, achieving pathologist-level precision even for typically challenging cell types, including tumor cells of immune origin. By democratizing rapidly deployable and scalable machine learning annotation, MAPS holds significant potential to expedite advances in tissue biology and disease comprehension.

Authors List :
Muhammad Shaban
Presenting Author :
Muhammad Shaban
Affiliations :
Mass General Brigham
Email :
mshaban@bwh.harvard.edu
Key Words (5 Words Maximum) :
Artificial Intelligence, Deep Learning, Medical Image Analysis, Multiplex Images
]]> Integrating Shellfish Biology with Technology: Applications in Marine Conservation, Water Quality, and Longevity Research https://assetonline.org/integrating-shellfish-biology-with-technology-applications-in-marine-conservation-water-quality-and-longevity-research/ Mon, 16 Dec 2024 05:14:20 +0000 https://assetonline.org/?p=5684 Shellfish are celebrated for their remarkable longevity and ecological importance, yet their growth, respiratory, and water filtration mechanisms remain underexplored in terms of technological and engineering applications. This study investigates these aspects, inspired by the discovery of an unusually large shellfish at Winger Seek Beach, to bridge marine biology with innovative solutions in environmental sustainability and bio-inspired engineering. Through a combination of advanced methodologies and experimental observations, this research uncovers original findings about shellfish physiology and highlights their potential for applications in water purification, respiratory device design, and environmental monitoring. To analyze the shellfish’s age and growth rate, growth rings on its shell were examined using adaptations of dendrochronological methods. These approaches provided precise age estimates of 23–27 years and refined existing techniques for interpreting growth patterns in long-lived marine organisms. This methodological advancement offers a valuable tool for studying other bivalves and contributes to understanding the slow-growth strategies associated with exceptional longevity in marine species. The findings highlight the role of shellfish as long-term recorders of environmental changes, opening pathways for their use in studying historical oceanic conditions. The respiratory mechanisms of the shellfish were analyzed by focusing on the structure and function of its gills. High-resolution imaging and computational modeling revealed how the extensive folding and microstructural organization of gill surfaces maximize gas exchange efficiency while minimizing energy expenditure. This study provided fresh insights into the biomechanics of shellfish respiration, identifying features that are not only evolutionarily optimized but also relevant to bioengineering. These findings have direct implications for the development of artificial respiratory systems and gas-exchange materials for medical and industrial use.
The study of water expulsion processes involved controlled experiments to observe siphon activity and filtration rates. Shellfish demonstrated the ability to filter significant volumes of water efficiently, maintaining homeostasis through precise regulation of siphon movements. This adaptive capability ensures functionality under varying environmental conditions such as salinity and temperature changes. These findings underscore the potential for shellfish-inspired filtration systems in water treatment technologies, particularly in regions facing challenges like pollution or seasonal water scarcity. By mimicking the efficiency and adaptability of shellfish filtration, engineers can design dynamic systems that process water effectively in diverse conditions.
These findings highlight the broader ecological and technological significance of shellfish. As natural bioindicators, shellfish can provide real-time data on water quality, pollution levels, and the impacts of climate change. Integrating shellfish physiology into IoT-enabled environmental monitoring systems could enhance efforts to safeguard aquatic ecosystems. Furthermore, their longevity and resilience offer valuable insights for understanding the genetic and physiological mechanisms underlying aging, with potential applications in regenerative medicine and aging research. In conclusion, this study advances our understanding of shellfish biology through original findings in growth analysis, gill efficiency, and water expulsion mechanisms. By linking these insights to engineering and environmental technologies, this research demonstrates how shellfish-inspired innovations can address pressing societal challenges, including clean water access, pollution control, and medical device development. Future studies will focus on scaling these applications, exploring genetic adaptations in shellfish, and integrating their functions into bio-inspired designs for sustainable solutions.

Authors List :
Erica Yasuhara
Presenting Author :
Erica Yasuhara
Affiliations :
Wellesley College
Email :
ericayasuhara@gmail.com
Key Words (5 Words Maximum) :
environment, water quality, engineering, longevity
]]> Preventing Aggregation of SOD1-D90A ALS-causing Mutant Using No-Mo-Aggregate-81 (NMA81) https://assetonline.org/preventing-aggregation-of-sod1-d90a-als-causing-mutant-using-no-mo-aggregate-81-nma81/ Mon, 16 Dec 2024 05:10:31 +0000 https://assetonline.org/?p=5682 Single mutations in the SOD1 protein, such as A4V and D90A, are known to induce aggregation of Superoxide dismutase 1 (SOD1) proteins, which is often universal for an amyotrophic lateral sclerosis (ALS) diagnosis. The D90A mutation is the most common of the ALS-causing point mutations and is known to show significant aggregation potential. This in silico inquiry was conducted on the D90A variant of the SOD1 protein, to create a molecule that could potentially inhibit aggregation. Through qualitative examination of the structures, it was determined that the residue Tryptophan 32 is an ideal target for the proposed small molecule. It differs sterically from the D90A mutant to the wild-type and is also distant from the dimerization and allosteric sites. These properties make it unlikely that the small molecule will interfere with the enzyme’s regular function when bound. No-Mo-Aggregate-81 (NMA81), a novel small molecule that specifically targets the Trp 32 residue, is proposed as potential treatment to prevent aggregation of the SOD1 proteins. Reduced aggregation of SOD1 is expected to be associated with decreased severity of ALS.

Authors List :
Ahad Asghar, Jasmine Jacobs, Karen Sabu Jose, Carrie (Roanna) Lu, Devnand Nambiar, Arjun Stenger, Hannah Zemans-Ronthal
Presenting Author :
Ahad Asghar, Arjun Stenger
Affiliations :
University of Western Ontario
Email :
ahadasghar2004@gmail.com
Key Words (5 Words Maximum) :
ALS, protein aggregation, in-silico, drug design
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