Cell based therapies for cancer: From Innovation to Translation

Cell based therapies are emerging as a promising strategy for cancer. We have developed cell surface receptor targeted adult stem cells, cancer cells and T cells expressing novel bi-functional immunomodulatory proteins and releasing oncolytic viruses. Using our recently established tumor models that mimic clinical settings, we have explored the fate and efficacy of different engineered cell based therapies. Our findings demonstrate the strength of using innovative approaches and clinically relevant preclinical models that pave a path for clinical translation. This presentation provides data and rationale for assessing combined cell based studies in preclinical studies and translating the most promising studies into the clinic.