The role of nutrients in immune modulation is well known. An immune modulation may involve stimulation of the immune system to enhance the cellular and humoral immunity in normal organisms, immune suppression of an overreactive immune system and/or restore immune functions in immunosuppressed organisms.  Ginger is commonly used as a spice worldwide and has been shown to possess numerous health benefits, including antioxidant, anti-inflammatory, antiviral, antibacterial, antidiabetic, and anticancer activities. Several studies have shown that ginger can modulate both humoral and cellular immunity to reduce inflammation, a critical response of innate immunity, by inhibiting the synthesis of pro-inflammatory mediators such as prostaglandins and leukotrienes and pro-inflammatory cytokines such as IL-1, TNF-α, and IL-8. Interestingly, ginger was very useful in resolving airway inflammation by suppressing Th2 cell-driven response to an allergen and reduced eosinophilia in the mice model of inflammation.  Furthermore, the ginger extract inhibited macrophage activation and indirectly inhibited T cell activation. More recent data suggest that ginger can play a role in inhibiting COVID-19 virus replication. The current scientific evidence suggests that ginger can be an effective nutrient to reduce the inflammation and cytokine storm during COVID19 infection.